Lymphotoxin-LIGHT Pathway Regulates the Interferon Signature in Rheumatoid Arthritis
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چکیده
منابع مشابه
Lymphotoxin-LIGHT Pathway Regulates the Interferon Signature in Rheumatoid Arthritis
A subset of patients with autoimmune diseases including rheumatoid arthritis (RA) and lupus appear to be exposed continually to interferon (IFN) as evidenced by elevated expression of IFN induced genes in blood cells. In lupus, detection of endogenous chromatin complexes by the innate sensing machinery is the suspected driver for the IFN, but the actual mechanisms remain unknown in all of these...
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Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting synovial joints. Therapies blocking tumor necrosis factor-alpha (TNFα) are now routinely used in the management of RA. However, a significant number of patients with RA do not respond or develop resistance to anti-TNF therapies, and the participation of other cytokines in RA pathogenesis has been reported as well. Lymphotoxin...
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OBJECTIVES Epigenetics can influence disease susceptibility and severity. While DNA methylation of individual genes has been explored in autoimmunity, no unbiased systematic analyses have been reported. Therefore, a genome-wide evaluation of DNA methylation loci in fibroblast-like synoviocytes (FLS) isolated from the site of disease in rheumatoid arthritis (RA) was performed. METHODS Genomic ...
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*Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224; †Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, and Basic Research Program, SAIC–Frederick, Inc., Frederick, MD 21702; and ‡Laboratory of Molecular Immunology, Engelhardt Institute of Molecular Biology, Russian Academy of Sci...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0112545